Famotidine

Synonyms: MK208

Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Famotidine  Chemical Structure

Famotidine Chemical Structure

CAS No. 76824-35-6

Purity & Quality Control

Batch: S207801 DMSO]67 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.48%
99.48

Famotidine Related Products

Biological Activity

Description Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.
Targets
H2 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06054464 Active not recruiting
Healthy Volunteers
PMV Pharmaceuticals Inc
September 19 2023 Phase 1
NCT04941755 Completed
Healthy Participants
Bristol-Myers Squibb
June 25 2021 Phase 1
NCT04614974 Active not recruiting
Laryngomalacia|Gastro Esophageal Reflux
Reema Padia|University of Pittsburgh
November 18 2020 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 337.45 Formula

C8H15N7O2S3

CAS No. 76824-35-6 SDF Download Famotidine SDF
Smiles C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (198.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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